SCHEMBL2921799

SCHEMBL2921799

C=CCOc1c(-c2ccccc2)cc(C)cc1[Si](C)(C)C1C=C(N2CCCCC2)c2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.33
MAPT P10636 2/20 0.32
SETDB1 Q15047 1/20 0.31
NPY5R Q15761 1/20 0.31
CDC7 O00311 1/20 0.31
ROS1 P08922 1/20 0.31
KIT P10721 1/20 0.31
MARK3 P27448 1/20 0.31
FLT3 P36888 1/20 0.31
CDK8 P49336 1/20 0.31
MAP2K1 Q02750 1/20 0.31
MAP3K10 Q02779 1/20 0.31
STK3 Q13188 1/20 0.31
MELK Q14680 1/20 0.31
LRRK2 Q5S007 1/20 0.31
MARK4 Q96L34 1/20 0.31
CAMKK2 Q96RR4 1/20 0.31
SIK2 Q9H0K1 1/20 0.31
CAMK2A Q9UQM7 1/20 0.31
MEN1 O00255 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2922482 0.99 SETDB1 (0.32) LMNAMAPTSETDB1MEN1KMT2A
SCHEMBL2923760 0.90 L3MBTL1 (0.36) LMNAMAPTSETDB1
SCHEMBL2923949 0.90 MAPT (0.33) MAPTSETDB1ALDH1A1KDM4E
SCHEMBL2922219 0.89 MAPT (0.31) MAPTSETDB1ALDH1A1KDM4E
SCHEMBL2916046 0.89 L3MBTL1 (0.34) MAPTSETDB1
SCHEMBL2923913 0.87 MAPT (0.31) MAPTSETDB1
SCHEMBL2922696 0.87 MAPT (0.31) MAPT
SCHEMBL2915859 0.86 SETDB1 (0.31) SETDB1
SCHEMBL2924295 0.86 CYP3A4 (0.31) MAPT
SCHEMBL2913420 0.83 CXCR5 (0.34) MAPTSETDB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1475383-B1 TRANSITION METAL COMPLEXES, LIGANDS, POLYMERIZATION CATALYSTS FOR OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2010-09-08 EP disclosed
US-7241927-B2 Transition metal complexes, ligands, catalysts for olefin polymerization, and process for production of olefin polymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-07-10 US disclosed
US-7141690-B2 Transition metal complexes, ligands, polymerization catalysts for olefins, and process for production of olefin polymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-11-28 US disclosed
US-20060111525-A1 Transition metal complexes, ligands, catalysts for olefin polymerization, and process for production of olefin polymers HANAOKA HIDENORI 2006-05-25 US disclosed
US-20050154158-A1 Transition metal complexes, ligands, polymerization catalysts for olefins, and process for production of olefin polymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-07-14 US disclosed
EP-1475383-A1 TRANSITION METAL COMPLEXES, LIGANDS, POLYMERIZATION CATALYSTS FOR OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS Sumitomo Chemical Company, Limited (JP) 2004-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050154158-A1 Transition metal complexes, ligands, polymerization catalysts for olefins, and process for production of olefin polymers PYM1, OR10J3, AP1M1 LMNA 4121/4885MAPT 3972/4885SETDB1 2026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.