SCHEMBL2923949

SCHEMBL2923949

C=CCOc1c([Si](C)(C)C)cc(C)cc1[Si](C)(C)C1C=C(N2CCCCC2)c2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HSD17B10 Q99714 1/20 0.31
GAA P10253 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
SETDB1 Q15047 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2922219 0.99 MAPT (0.31) MAPTKDM4EALDH1A1HSD17B10SETDB1
SCHEMBL2923760 0.93 L3MBTL1 (0.36) MAPTSETDB1L3MBTL1HRH3
SCHEMBL2916046 0.92 L3MBTL1 (0.34) MAPTSETDB1L3MBTL1
SCHEMBL2923913 0.91 MAPT (0.31) MAPTSETDB1HRH3
SCHEMBL2921799 0.90 LMNA (0.33) MAPTKDM4EALDH1A1SETDB1
SCHEMBL2915859 0.90 SETDB1 (0.31) SETDB1
SCHEMBL2922696 0.90 MAPT (0.31) MAPTHRH3
SCHEMBL2922482 0.89 SETDB1 (0.32) MAPTSETDB1
SCHEMBL2924295 0.89 CYP3A4 (0.31) MAPT
SCHEMBL2913420 0.85 CXCR5 (0.34) MAPTALDH1A1SETDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1475383-B1 TRANSITION METAL COMPLEXES, LIGANDS, POLYMERIZATION CATALYSTS FOR OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2010-09-08 EP disclosed
US-7241927-B2 Transition metal complexes, ligands, catalysts for olefin polymerization, and process for production of olefin polymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-07-10 US disclosed
US-7141690-B2 Transition metal complexes, ligands, polymerization catalysts for olefins, and process for production of olefin polymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-11-28 US disclosed
US-20060111525-A1 Transition metal complexes, ligands, catalysts for olefin polymerization, and process for production of olefin polymers HANAOKA HIDENORI 2006-05-25 US disclosed
US-20050154158-A1 Transition metal complexes, ligands, polymerization catalysts for olefins, and process for production of olefin polymers SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-07-14 US disclosed
EP-1475383-A1 TRANSITION METAL COMPLEXES, LIGANDS, POLYMERIZATION CATALYSTS FOR OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS Sumitomo Chemical Company, Limited (JP) 2004-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050154158-A1 Transition metal complexes, ligands, polymerization catalysts for olefins, and process for production of olefin polymers PYM1, OR10J3, AP1M1 MAPT 3972/4885KDM4E 3424/4885ALDH1A1 2570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.