Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 9/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218519 | 0.88 | CNR2 (0.37) | NPC1MAPTRAB9ACNR2DRD3 | |
| SCHEMBL31008927 | 0.88 | NPC1 (0.36) | NPC1MAPTRAB9ACNR2DRD3 | |
| SCHEMBL29218782 | 0.84 | CNR2 (0.38) | NPC1MAPTRAB9ACNR2DRD3 | |
| SCHEMBL29218648 | 0.82 | MAOB (0.39) | NPC1MAPTRAB9AMAOBMAOA | |
| SCHEMBL29218629 | 0.76 | MAOB (0.37) | NPC1MAPTRAB9AMAOBMAOA | |
| SCHEMBL25041820 | 0.71 | DRD2 (0.36) | NPC1MAPTRAB9ACNR2DRD3 | |
| SCHEMBL779443 | 0.71 | NPC1 (0.58) | NPC1MAPTRAB9ACNR2MAOB | |
| SCHEMBL31008881 | 0.70 | MAOB (0.35) | NPC1MAPTRAB9AMAOBMAOA | |
| SCHEMBL31008976 | 0.70 | MAOB (0.35) | NPC1MAPTRAB9AMAOBMAOA | |
| SCHEMBL29218632 | 0.70 | MAOA (0.35) | MAOBMAOAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384493-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd (KY) | 2024-06-19 | — | — | EP | disclosed |
| CN-118076581-A | Iron death modulators, their preparation and use | 维泰瑞隆有限公司 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023016447-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2023-02-16 | — | — | WO | disclosed |