Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.33 |
| ▸ | IL1B | P01584 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30825164 | 1.00 | CHRM4 (0.37) | CHRM4CCR1EPHX2CHRM2CHRM1 | |
| SCHEMBL29226658 | 0.86 | CHRM4 (0.37) | CHRM4CCR1CHRM2CHRM1CHRM3 | |
| SCHEMBL30900418 | 0.86 | CHRM4 (0.37) | CHRM4CCR1CHRM2CHRM1CHRM3 | |
| SCHEMBL30825150 | 0.86 | CHRM4 (0.36) | CHRM4EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL30900288 | 0.86 | MEN1 (0.41) | CCR1MAPTSMN1; SMN2TRPC6 | |
| SCHEMBL29226248 | 0.86 | MEN1 (0.41) | CCR1MAPTSMN1; SMN2TRPC6 | |
| SCHEMBL30900290 | 0.86 | CHRM4 (0.39) | CHRM4EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL29226246 | 0.86 | CHRM4 (0.39) | CHRM4EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL29226215 | 0.81 | NR1H2 (0.46) | CCR1 | |
| SCHEMBL30900401 | 0.77 | SUV39H2 (0.40) | CHRM4EPHX2NOTUMMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117658987-A | Compounds as PLK1 inhibitors, and preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-03-08 | — | — | CN | disclosed |