Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.79 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.77 |
| ▸ | MEN1 | O00255 | 6/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.46 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20379584 | 0.87 | LMNA (0.67) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL29227225 | 0.86 | LMNA (0.69) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL30873570 | 0.84 | LMNA (0.65) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL29227158 | 0.81 | LMNA (0.62) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL20380310 | 0.81 | PRMT5 (0.85) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL29227112 | 0.79 | LMNA (0.60) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL24169175 | 0.79 | ATM (0.80) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL30758060 | 0.79 | ATM (0.80) | PRMT5WDR77KMT2AMEN1LMNA | |
| SCHEMBL29227117 | 0.78 | LMNA (0.59) | PRMT5WDR77KMT2AMEN1LMNA | |
| Hydrochloric Acid SCHEMBL25286486 | 0.78 | ATM (0.78) | PRMT5WDR77KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946031-A | Substituted aromatic phenol derivatives of KNa1.1 channel inhibitors | 北京大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117946031-A | Substituted aromatic phenol derivatives of KNa1.1 channel inhibitors | 北京大学 | 2024-04-30 | — | — | CN | disclosed |