Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
| ▸ | F11 | P03951 | 5/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | USP8 | P40818 | 2/20 | 0.31 |
| ▸ | USP7 | Q93009 | 2/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29227926 | 0.89 | P4HTM (0.38) | NOTUMF11P4HTMKLKB1 | |
| SCHEMBL24633366 | 0.87 | NOTUM (0.39) | NOTUMF11KLKB1 | |
| SCHEMBL31174105 | 0.87 | NOTUM (0.39) | NOTUMF11KLKB1 | |
| SCHEMBL28514409 | 0.86 | F11 (0.45) | F11KLKB1 | |
| SCHEMBL29227943 | 0.82 | F11 (0.42) | NOTUMF11P4HTMKLKB1KCNH2 | |
| SCHEMBL30995020 | 0.80 | F11 (0.41) | F11KLKB1 | |
| SCHEMBL24633487 | 0.80 | F11 (0.41) | F11KLKB1 | |
| SCHEMBL29227925 | 0.80 | F11 (0.39) | NOTUMF11P4HTMKLKB1KCNH2 | |
| SCHEMBL29227932 | 0.78 | F11 (0.39) | NOTUMF11P4HTMKLKB1USP8 | |
| SCHEMBL24633461 | 0.76 | F11 (0.41) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126046-A | Substituted macrocyclic compound, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-06-04 | — | — | CN | disclosed |