SCHEMBL29228917

SCHEMBL29228917

COc1ccc(S(=O)(=O)N2CCc3cc(C(=O)O)n(C)c3C2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 5/20 0.58
AKR1C3 P42330 4/20 0.53
PDE4B Q07343 1/20 0.49
PDE4D Q08499 1/20 0.49
NPC1 O15118 1/20 0.49
PKLR P30613 1/20 0.49
RAB9A P51151 1/20 0.49
LMNA P02545 2/20 0.47
ALDH1A1 P00352 3/20 0.46
USP2 O75604 1/20 0.46
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
TAS2R14 Q9NYV8 2/20 0.45
TUBB4A P04350 1/20 0.45
TUBB P07437 1/20 0.45
TUBA3C P0DPH7 1/20 0.45
TUBA1B P68363 1/20 0.45
TUBA4A P68366 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29228903 0.87 MEN1 (0.55) AKR1C3
SCHEMBL29228879 0.86 PKM (0.53) PKMAKR1C3PDE4BPDE4DNPC1
SCHEMBL975529 0.78 AKR1C3 (0.49) PKMAKR1C3ALDH1A1KDM4E
SCHEMBL29228933 0.78 ESR1 (0.47) AKR1C3NPC1RAB9AALDH1A1CYP3A4
SCHEMBL3281251 0.77 AKR1C3 (0.76) PKMAKR1C3PDE4BPDE4DLMNA
SCHEMBL1656120 0.76 PKM (0.45) PKMAKR1C3NPC1PKLRRAB9A
SCHEMBL30458170 0.76 CYP2C9 (0.48) AKR1C3RAB9ALMNAALDH1A1GAA
SCHEMBL3061348 0.71 PKM (0.84) PKMAKR1C3PDE4BPDE4DNPC1
SCHEMBL6036911 0.71 PKM (0.77) PKMNPC1PKLRRAB9ALMNA
SCHEMBL12922701 0.71 MAOA (0.39) ALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118139864-A New compounds 西特瑞治疗有限公司 2024-06-04 CN disclosed