Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL418353 | 0.87 | ABCB11 (0.30) | ALDH1A1HSD17B10 | |
| Acridine SCHEMBL28191176 | 0.75 | MAPT (0.39) | KDM4EMEN1ALDH1A1MAPTPKM | |
| SCHEMBL8576907 | 0.71 | — | — | |
| SCHEMBL10642347 | 0.70 | ALDH1A1 (0.33) | KDM4EMEN1ALDH1A1LMNABCHE | |
| SCHEMBL2044078 | 0.68 | — | — | |
| SCHEMBL10692738 | 0.66 | — | — | |
| SCHEMBL2047541 | 0.66 | — | — | |
| SCHEMBL11089569 | 0.65 | KDM4E (0.32) | KDM4EMEN1ALDH1A1LMNABCHE | |
| SCHEMBL10375401 | 0.64 | CFTR (0.32) | — | |
| SCHEMBL17284106 | 0.64 | SETD7 (0.33) | MEN1ALDH1A1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231675-A1 | PROCESS FOR THE PREPARATION OF 5-CYCLOPROPYL-5, 11-DIHYDRO (1) BENZOXEPINO (3, 4-B) -PYRIDIN-5-OL USING TMEDA | Millennium Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009073462-A1 | PROCESS FOR THE PREPARATION OF 5-CYCLOPROPYL-5, 11-DIHYDRO (1) BENZOXEPINO (3, 4-B) -PYRIDIN-5-OL USING TMEDA | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-11 | — | — | WO | disclosed |