Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 13/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.31 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24664589 | 1.00 | HDAC6 (0.35) | HDAC6PSMB9CFDITGA4GPR88 | |
| SCHEMBL29230784 | 0.89 | ITGA4 (0.35) | HDAC6PSMB9CFDITGA4 | |
| SCHEMBL29230781 | 0.89 | ITGA4 (0.35) | HDAC6PSMB9CFDITGA4 | |
| SCHEMBL24665866 | 0.89 | ITGA4 (0.35) | HDAC6PSMB9CFDITGA4 | |
| SCHEMBL29820279 | 0.88 | GPR88 (0.36) | PSMB9CFDITGA4GPR88 | |
| SCHEMBL24664659 | 0.88 | GPR88 (0.36) | PSMB9CFDITGA4GPR88 | |
| SCHEMBL26832888 | 0.87 | TACR1 (0.40) | HDAC6CFDGPR88 | |
| SCHEMBL24664461 | 0.87 | PSMB9 (0.34) | PSMB9CFDITGA4 | |
| SCHEMBL30341256 | 0.87 | PSMB9 (0.34) | PSMB9CFDITGA4 | |
| SCHEMBL29230539 | 0.87 | PSMB9 (0.34) | PSMB9CFDITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117956985-A | Inhibitors of glycogen synthase 1 (GYS 1) and methods of use thereof | 梅兹治疗公司 | 2024-04-30 | — | — | CN | disclosed |
| EP-4308095-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | Maze Therapeutics, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |