Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24440376 | 1.00 | TDP1 (0.62) | TDP1TSHRSMN1; SMN2GLAMAPT | |
| Hydrochloric Acid SCHEMBL29238521 | 0.98 | TDP1 (0.60) | TDP1TSHRSMN1; SMN2GLAMAPT | |
| SCHEMBL12767842 | 0.85 | TDP1 (0.67) | TDP1TSHRSMN1; SMN2GLAMAPT | |
| SCHEMBL30100732 | 0.83 | ALDH1A1 (0.53) | TDP1TSHRSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL30487743 | 0.83 | ALDH1A1 (0.53) | TDP1TSHRSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL16011382 | 0.83 | ALDH1A1 (0.53) | TDP1TSHRSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL888030 | 0.83 | ALDH1A1 (0.53) | TDP1TSHRSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL31134288 | 0.83 | ALDH1A1 (0.53) | TDP1TSHRSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL16950686 | 0.82 | TDP1 (0.62) | TDP1TSHRSMN1; SMN2GLAMAPT | |
| SCHEMBL6676584 | 0.82 | TDP1 (0.62) | TDP1TSHRSMN1; SMN2GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4417607-A1 | HETEROCYCLIC COMPOUND AS SOS1 INHIBITOR AND USES THEREOF | Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) | 2024-08-21 | — | — | EP | disclosed |
| CN-117957226-A | Heterocyclic compounds as SOS1 inhibitors and uses thereof | 南京再明医药有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117062818-A | Novel SOS1 inhibitor and preparation method and application thereof | 南京再明医药有限公司 | 2023-11-14 | — | — | CN | disclosed |
| WO-2023041049-A1 | HETEROCYCLIC COMPOUND AS SOS1 INHIBITOR AND USES THEREOF | 江苏先声药业有限公司 | 2023-03-23 | — | — | WO | disclosed |
| WO-2022184116-A1 | NEW SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏先声药业有限公司 | 2022-09-09 | — | — | WO | disclosed |