Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29238864 | 0.81 | CYP11B2 (0.45) | — | |
| SCHEMBL4771510 | 0.78 | ALOX15 (0.51) | GPR35KDM4EL3MBTL1ALOX15TDP1 | |
| SCHEMBL4772437 | 0.75 | MKNK1 (0.49) | KDM4EALDH1A1MCL1 | |
| SCHEMBL29238863 | 0.74 | PRKCQ (0.36) | KDM4EACVR1TGFBR1 | |
| SCHEMBL4769459 | 0.73 | DHODH (0.49) | — | |
| SCHEMBL4772052 | 0.72 | ALOX15 (0.46) | GPR35KDM4EALOX15LMNATDP1 | |
| SCHEMBL4778161 | 0.71 | HCAR2 (0.47) | GPR35KDM4EALOX15ALDH1A1MCL1 | |
| SCHEMBL4779431 | 0.70 | HCAR2 (0.39) | GPR35KDM4EALOX15ALDH1A1MCL1 | |
| SCHEMBL4769103 | 0.70 | MCL1 (0.64) | KDM4EL3MBTL1ALDH1A1MCL1 | |
| SCHEMBL4778496 | 0.70 | ABL1 (0.41) | GPR35KDM4EALOX15TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118251390-A | Heteroaryl linked analogs as MGLU5 negative allosteric modulators and methods of making and using the same | 范德比尔特大学 | 2024-06-25 | — | — | CN | disclosed |