Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089798 | 0.75 | ADORA2B (0.53) | ADORA2BHPGDADORA2AADORA1NPC1 | |
| SCHEMBL23089162 | 0.74 | ADORA2B (0.48) | ADORA2BHPGDADORA2AADORA1NPC1 | |
| SCHEMBL29736596 | 0.74 | ADORA2B (0.48) | ADORA2BHPGDADORA2AADORA1NPC1 | |
| SCHEMBL23089463 | 0.73 | HPGD (0.51) | ADORA2BHTTHPGDADORA2AADORA1 | |
| SCHEMBL29736825 | 0.73 | ADORA2B (0.47) | ADORA2BHPGDADORA2AADORA1NPC1 | |
| SCHEMBL23089787 | 0.73 | ADORA2B (0.47) | ADORA2BHPGDADORA2AADORA1NPC1 | |
| SCHEMBL30865569 | 0.72 | L3MBTL1 (0.46) | HTTNPC1RAB9AALDH1A1ALOX12 | |
| SCHEMBL23104750 | 0.72 | ADORA2B (0.46) | ADORA2BHPGDADORA2AADORA1NPC1 | |
| SCHEMBL23104332 | 0.70 | HPGD (0.46) | ADORA2BHTTHPGDNPC1HSP90AA1 | |
| SCHEMBL23089495 | 0.70 | HPGD (0.48) | ADORA2BHPGDADORA2AADORA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |