Citric Acid

Citric Acid

SCHEMBL2924252

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CN(CCO)CC(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.46
MEN1 known ✓ O00255 3/20 0.41
SCN1A known ✓ P35498 1/20 0.33
SCN2A known ✓ Q99250 1/20 0.33
SCN3A known ✓ Q9NY46 1/20 0.33
ALDH1A1 P00352 2/20 0.58
TDP1 Q9NUW8 2/20 0.48
EYA2 O00167 1/20 0.48
APP P05067 1/20 0.48
ACE P12821 1/20 0.48
KDM4E B2RXH2 8/20 0.46
LMNA P02545 8/20 0.46
ALOX15 P16050 4/20 0.46
TSHR P16473 3/20 0.46
BLM P54132 2/20 0.46
PMP22 Q01453 2/20 0.46
CYP2C19 P33261 2/20 0.46
ADRA1A P35348 2/20 0.46
CHRM2 P08172 1/20 0.46
ADRA2A P08913 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL10635562 0.96 ALDH1A1 (0.58) ALDH1A1TDP1EYA2APPACE
Citric Acid SCHEMBL5474506 0.90 ALDH1A1 (0.65) ALDH1A1KDM4ELMNAALOX15TSHR
Edetic Acid SCHEMBL9707163 0.90 ALDH1A1 (0.65) ALDH1A1TDP1EYA2APPACE
Edetic Acid SCHEMBL1684283 0.90 ALDH1A1 (0.65) ALDH1A1TDP1EYA2APPACE
Citric Acid SCHEMBL3851025 0.90 ALDH1A1 (0.65) ALDH1A1KDM4ELMNAALOX15TSHR
Edetic Acid SCHEMBL17162123 0.88 ALDH1A1 (0.62) ALDH1A1TDP1EYA2APPACE
Edetic Acid SCHEMBL9067296 0.88 ALDH1A1 (0.62) ALDH1A1TDP1EYA2APPACE
Pentetic Acid SCHEMBL8606808 0.88 KDM4E (0.62) ALDH1A1TDP1EYA2APPACE
Edetic Acid SCHEMBL21433561 0.88 ALDH1A1 (0.62) ALDH1A1TDP1EYA2APPACE
Edetic Acid SCHEMBL7761651 0.88 ALDH1A1 (0.62) ALDH1A1TDP1EYA2APPACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0741772-B2 HIGH SUDSING LIGHT DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS CONTAINING LONG CHAIN AMINE OXIDE PROCTER & GAMBLE (US) 2010-09-08 EP disclosed
EP-0719321-B2 LIGHT DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS CONTAINING PROTEASE PROCTER & GAMBLE (US) 2009-03-25 EP disclosed
EP-1023426-B1 LIGHT-DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS COMPRISING MID-CHAIN BRANCHED SURFACTANTS PROCTER & GAMBLE (US) 2005-02-09 EP disclosed
EP-0878535-B1 Light-duty liquid or gel dishwashing detergent compositions which are microemulsions and which have desirable greasy food soil removal and sudsing characteristics. PROCTER & GAMBLE (US) 2003-04-16 EP disclosed
US-6387856-B1 COMPLEX OF IODINE WITH SURFACTANT; AQUEOUS SOLUTION PROCTER & GAMBLE COMPANY 2002-05-14 US disclosed
US-6281181-B1 Light-duty liquid or gel dishwashing detergent compositions comprising mid-chain branched surfactants THE PROCTER & GAMBLE COMPANY 2001-08-28 US disclosed
US-6162778-A Light-duty liquid or gel dishwashing detergent compositions having beneficial skin conditioning, skin feel and rinsability aesthetics THE PROCTER & GAMBLE COMPANY (US) 2000-12-19 US disclosed
EP-1023426-A1 LIGHT-DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS COMPRISING MID-CHAIN BRANCHED SURFACTANTS THE PROCTER & GAMBLE COMPANY (US) 2000-08-02 EP disclosed
EP-0994934-A1 LIGHT-DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS HAVING CONTROLLED pH AND DESIRABLE FOOD SOIL REMOVAL, RHEOLOGICAL AND SUDSING CHARACTERISTICS THE PROCTER & GAMBLE COMPANY (US) 2000-04-26 EP disclosed
EP-0988359-A1 LIGHT-DUTY LIQUID DISHWASHING DETERGENT COMPOSITIONS WHICH HAVE DESIRABLE LOW TEMPERATURE STABILITY AND DESIRABLE GREASY SOIL REMOVAL AND SUDSING CHARACTERISTICS THE PROCTER & GAMBLE COMPANY (US) 2000-03-29 EP disclosed
EP-0878535-A1 Light-duty liquid or gel dishwashing detergent compositions which are microemulsions and which have desirable greasy food soil removal and sudsing characteristics. THE PROCTER & GAMBLE COMPANY (US) 1998-11-18 EP disclosed
US-5726141-A Low sudsing detergent compositions containing long chain amine oxide and branched alkyl carboxylates THE PROCTER & GAMBLE COMPANY (US) 1998-03-10 US disclosed
US-5698505-A IMPROVED GREASE EMULSIFICATION THE PROCTER & GAMBLE COMPANY (US) 1997-12-16 US disclosed
WO-1997025397-A1 LIGHT-DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS HAVING BENEFICIAL SKIN CONDITIONING, SKIN FEEL AND RINSABILITY AESTHETICS THE PROCTER & GAMBLE COMPANY (US) 1997-07-17 WO disclosed
US-5599400-A IMMERSING HANDS WITH REDUCED SKIN IRRITATION WHILE MANUALLYWASHING DISHES/HANDS THE PROCTER & GAMBLE COMPANY (US) 1997-02-04 US disclosed
EP-0741772-A1 HIGH SUDSING LIGHT DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS CONTAINING LONG CHAIN AMINE OXIDE THE PROCTER & GAMBLE COMPANY (US) 1996-11-13 EP disclosed
EP-0741770-A1 LOW SUDSING DETERGENT COMPOSITIONS CONTAINING LONG CHAIN AMINE OXIDE AND BRANCHED ALKYL CARBOXYLATES THE PROCTER & GAMBLE COMPANY (US) 1996-11-13 EP disclosed
WO-1995020028-A1 LOW TO MODERATE SUDSING DETERGENT COMPOSITIONS CONTAINING LONG CHAIN AMINE OXIDE THE PROCTER & GAMBLE COMPANY (US) 1995-07-27 WO disclosed
WO-1995020027-A1 HIGH SUDSING LIGHT DUTY LIQUID OR GEL DISHWASHING DETERGENT COMPOSITIONS CONTAINING LONG CHAIN AMINE OXIDE THE PROCTER & GAMBLE COMPANY (US) 1995-07-27 WO disclosed
WO-1995020025-A1 LOW SUDSING DETERGENT COMPOSITIONS CONTAINING LONG CHAIN AMINE OXIDE AND BRANCHED ALKYL CARBOXYLATES THE PROCTER & GAMBLE COMPANY (US) 1995-07-27 WO disclosed