Citric Acid

Citric Acid

SCHEMBL3851025

O=C(O)CC(O)(CC(=O)O)C(=O)O.OCCN(CCO)CCO.OCCN(CCO)CCO.OCCN(CCO)CCO

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 2/20 0.44
ALDH1A1 P00352 2/20 0.65
KDM4E B2RXH2 7/20 0.44
LMNA P02545 6/20 0.44
CYP2D6 P10635 4/20 0.44
CYP1A2 P05177 3/20 0.44
KMT2A Q03164 2/20 0.44
MAPT P10636 4/20 0.39
TSHR P16473 2/20 0.39
ALOX15 P16050 2/20 0.39
HMGCR P04035 1/20 0.36
CHRM1 P11229 1/20 0.36
TBXA2R P21731 1/20 0.36
ADRA1A P35348 1/20 0.36
HIF1A Q16665 2/20 0.35
SLC13A5 Q86YT5 4/20 0.35
CYP2C19 P33261 1/20 0.34
ACLY P53396 3/20 0.34
TP53 P04637 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL5474506 1.00 ALDH1A1 (0.65) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL29168513 0.98 ALDH1A1 (0.62) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL27294006 0.92 ALDH1A1 (0.56) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL2924252 0.90 ALDH1A1 (0.58) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL10635562 0.90 ALDH1A1 (0.58) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL1131810 0.88 KDM4E (0.50) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL28089489 0.88 ALDH1A1 (0.50) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL426935 0.84 ALDH1A1 (0.83) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL2636987 0.84 ALDH1A1 (0.83) ALDH1A1KDM4ELMNACYP2D6CYP1A2
Citric Acid SCHEMBL1131197 0.83 ALDH1A1 (0.60) ALDH1A1KDM4ELMNACYP2D6CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240138403-A1 Synergistic Combinations for Reducing Volatility of Auxin Herbicides ETHOX CHEMICALS, LLC 2024-05-02 US claimed
US-20230021295-A1 Synergistic Combinations for Reducing Volatility of Auxin Herbicides ETHOX CHEMICALS, LLC 2023-01-19 US claimed
WO-2023278670-A1 SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES ETHOX CHEMICALS, LLC (US) 2023-01-05 WO claimed
WO-2002086046-A2 MULTI-PHASE CONDITIONING AGENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-10-31 WO claimed
WO-2002048308-A1 AQUEOUS MULTIPHASE CLEANING AGENT OF DIFFERENT COLORS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-06-20 WO claimed
EP-1214395-A1 ANTI-MICROBIAL, AQUEOUS, MULTI-PHASE CLEANING AGENT Henkel Kommanditgesellschaft auf Aktien (DE) 2002-06-19 EP claimed
EP-1141225-A1 AQUEOUS MULTI-PHASE CLEANING AGENT Henkel Kommanditgesellschaft auf Aktien (DE) 2001-10-10 EP claimed
WO-2001030958-A1 AQUEOUS MULTIPLE PHASE DETERGENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2001-05-03 WO claimed
WO-2001021753-A1 ANTI-MICROBIAL, AQUEOUS, MULTI-PHASE CLEANING AGENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2001-03-29 WO claimed
WO-2000039270-A1 AQUEOUS MULTI-PHASE CLEANING AGENT HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2000-07-06 WO claimed
US-20240138403-A1 Synergistic Combinations for Reducing Volatility of Auxin Herbicides ETHOX CHEMICALS, LLC 2024-05-02 US disclosed
US-20230021295-A1 Synergistic Combinations for Reducing Volatility of Auxin Herbicides ETHOX CHEMICALS, LLC 2023-01-19 US disclosed
WO-2023278670-A1 SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES ETHOX CHEMICALS, LLC (US) 2023-01-05 WO disclosed
EP-3518881-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION Henkel AG & Co. KGaA (DE) 2019-08-07 EP disclosed
EP-3518889-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION Henkel AG & Co. KGaA (DE) 2019-08-07 EP disclosed
US-4247423-A CHEMICAL INTERMEDIATES OF 2-OXABICYCLO(2.2.2)OCTANE DERIVATIVES; FOODS; TOBACCO INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1981-01-27 US disclosed
US-4238344-A ALCOHOL AND ESTER DERIVATIVES OF CYCLOHEXENE; 2-OXABICYCLO(2.2.2)OCTANES INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-12-09 US disclosed
US-4231940-A 2-Oxabicyclooctane derivatives INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-11-04 US disclosed
US-4207214-A 2-Oxabicyclooctane derivatives in perfume compositions INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-06-10 US disclosed
US-4195099-A Use of 2-oxabicyclooctane derivatives, for augmenting or enhancing the flavor of foodstuffs INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-03-25 US disclosed