SCHEMBL29258100

SCHEMBL29258100

Cc1cccc(CNS(=O)(=O)c2ccc(NC(=O)/C=C/c3ccncc3)cc2)c1

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 15/20 0.69
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
MAPT P10636 1/20 0.57
GPR17 Q13304 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30927201 1.00 NAMPT (0.69) NAMPTMEN1KMT2AMAPTGPR17
SCHEMBL29258286 0.89 MEN1 (0.56) NAMPTMEN1KMT2AMAPT
SCHEMBL30927236 0.89 NAMPT (0.68) NAMPTMEN1KMT2AMAPT
SCHEMBL29258225 0.89 NAMPT (0.68) NAMPTMEN1KMT2AMAPT
SCHEMBL29258194 0.89 NAMPT (0.68) NAMPTMEN1KMT2AMAPTGPR17
SCHEMBL30927229 0.89 NAMPT (0.68) NAMPTMEN1KMT2AMAPTGPR17
SCHEMBL30927215 0.89 MEN1 (0.56) NAMPTMEN1KMT2AMAPT
SCHEMBL29258519 0.89 NAMPT (0.67) NAMPTMEN1KMT2AMAPT
SCHEMBL30927217 0.89 NAMPT (0.69) NAMPT
SCHEMBL29258283 0.89 NAMPT (0.69) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN claimed
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN disclosed