SCHEMBL29258273

SCHEMBL29258273

O=C(NCc1ccncc1)Nc1ccc(C(=O)NCc2ccc(Br)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 20/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20379936 0.92 NAMPT (0.80) NAMPT
SCHEMBL29258535 0.90 NAMPT (0.67) NAMPT
SCHEMBL29258559 0.89 NAMPT (0.65) NAMPT
SCHEMBL30927222 0.89 NAMPT (0.65) NAMPT
SCHEMBL29258723 0.88 NAMPT (0.71) NAMPT
SCHEMBL20379448 0.88 HTT (0.68) NAMPT
SCHEMBL9422508 0.88 MMP13 (0.68)
SCHEMBL29258364 0.87 NAMPT (0.64) NAMPT
SCHEMBL29258680 0.87 NAMPT (0.64) NAMPT
SCHEMBL20379630 0.87 NAMPT (0.88) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN claimed
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN disclosed