SCHEMBL29258281

SCHEMBL29258281

O=C(NCc1ccncc1)Nc1ccc(C(=O)NCc2cccc(C(F)(F)F)c2)cc1

nearest known ligand 0.72

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 16/20 0.72
MLYCD O95822 1/20 0.63
MTOR P42345 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29258285 0.90 NAMPT (0.85) NAMPTMTOR
SCHEMBL1568282 0.86 MLYCD (0.74) NAMPTMLYCD
SCHEMBL20379195 0.86 NAMPT (0.80) NAMPT
SCHEMBL30927240 0.86 NAMPT (0.80) NAMPT
SCHEMBL11614113 0.85 NAMPT (1.00) NAMPTMTOR
SCHEMBL29258279 0.85 NAMPT (0.82) NAMPT
SCHEMBL11616056 0.84 NAMPT (0.74) NAMPTMTOR
SCHEMBL20379936 0.84 NAMPT (0.80) NAMPT
SCHEMBL5227678 0.84 MLYCD (0.86) MLYCD
SCHEMBL20379297 0.84 NAMPT (1.00) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN claimed
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN disclosed