SCHEMBL29258285

SCHEMBL29258285

O=C(NCc1ccncc1)Nc1ccc(C(=O)NCc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 19/20 0.85
MTOR P42345 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11614113 0.92 NAMPT (1.00) NAMPTMTOR
SCHEMBL20379936 0.91 NAMPT (0.80) NAMPT
SCHEMBL29258281 0.90 NAMPT (0.72) NAMPTMTOR
SCHEMBL20379290 0.89 NAMPT (0.88) NAMPT
SCHEMBL11628816 0.88 NAMPT (0.67) NAMPT
SCHEMBL29258634 0.87 NAMPT (0.89) NAMPT
SCHEMBL29258723 0.87 NAMPT (0.71) NAMPT
Hydrochloric Acid SCHEMBL11627973 0.87 SORT1 (0.65) NAMPT
SCHEMBL20379933 0.86 NAMPT (0.88) NAMPT
SCHEMBL20379630 0.86 NAMPT (0.88) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN claimed
CN-118108664-A NAMPT agonist and preparation method and application thereof 中国人民解放军海军军医大学 2024-05-31 CN disclosed