Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152301 | 0.82 | ENPP2 (0.47) | MEN1MAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL1401653 | 0.80 | SMN1; SMN2 (0.48) | MEN1MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL2815195 | 0.77 | ALDH1A1 (0.47) | MEN1MAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL29780594 | 0.77 | ALDH1A1 (0.47) | MEN1MAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8596113 | 0.77 | MAOB (0.56) | MEN1MAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8598664 | 0.76 | TSHR (0.46) | MEN1MAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL30963179 | 0.74 | MAPT (0.51) | MEN1MAPTKMT2AALDH1A1POLB | |
| SCHEMBL347820 | 0.74 | TSHR (0.61) | MEN1MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL29034464 | 0.74 | MAPT (0.53) | MEN1MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL30963150 | 0.71 | F2RL3 (0.51) | MEN1MAPTKMT2AALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553097-B1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS AND INTERMEDIATES THEREFORE | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | disclosed |