Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 5/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18411434 | 0.84 | GRIA1 (0.53) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL18411316 | 0.82 | GRIA1 (0.52) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL3475505 | 0.81 | GRIA1 (0.52) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL4463772 | 0.79 | GRIA1 (0.50) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL973015 | 0.78 | GRIA1 (0.51) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL30102603 | 0.78 | GRIA1 (0.51) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL31070227 | 0.78 | GRIA1 (0.51) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL2918046 | 0.77 | GRIA1 (0.56) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| SCHEMBL5046202 | 0.77 | GRIA1 (0.48) | GRIA1GRIA3PDE4DGRM5GABRG2 | |
| Water SCHEMBL4777578 | 0.77 | GRIA1 (0.56) | GRIA1GRIA3PDE4DGRM5GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222296-A2 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR EPILEPSY | Eisai R&D Management Co., Ltd. (JP) | 2010-09-01 | — | — | EP | disclosed |
| EP-2164488-A1 | AMPA RECEPTOR ANTAGONISTS AND ALDOSE REDUCTASE INHIBITORS FOR NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009082038-A2 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR EPILEPSY | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009011410-A1 | AMPA RECEPTOR ANTAGONISTS AND ALDOSE REDUCTASE INHIBITORS FOR NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |