Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921927 | 0.78 | GRIA1 (0.33) | GABRA1GABRG2GABRB3GABRA2GABRA5 | |
| SCHEMBL1881485 | 0.74 | GRIA1 (0.58) | KMT2AKDM4EALDH1A1GLAGAA | |
| SCHEMBL2926367 | 0.68 | GRIA1 (0.44) | KDM4EALDH1A1GLAGAAGRIA1 | |
| SCHEMBL2461016 | 0.65 | BCAT2 (0.47) | KMT2AALDH1A1 | |
| SCHEMBL27744470 | 0.64 | KMT2A (0.49) | KMT2AKDM4EALDH1A1HTR1A | |
| SCHEMBL3671759 | 0.64 | MCL1 (0.40) | KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL24508433 | 0.63 | PTGS1 (0.40) | KMT2AKDM4EGAASMN1; SMN2 | |
| SCHEMBL29923073 | 0.63 | ALDH1A1 (0.43) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30679663 | 0.63 | RORB (0.49) | KMT2AGAA | |
| SCHEMBL16399829 | 0.63 | HSD17B1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164488-A1 | AMPA RECEPTOR ANTAGONISTS AND ALDOSE REDUCTASE INHIBITORS FOR NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009011410-A1 | AMPA RECEPTOR ANTAGONISTS AND ALDOSE REDUCTASE INHIBITORS FOR NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |