Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923596 | 0.84 | CCNA2 (0.42) | CCNA2CDK2CCNA1CCNB2CCNE2 | |
| SCHEMBL2916852 | 0.83 | CCNA2 (0.49) | CCNA2CDK2CCNA1CCNB2CCNE2 | |
| SCHEMBL2924758 | 0.79 | KDM4E (0.45) | CCNA2CDK2CCNA1CCNB2CCNE2 | |
| SCHEMBL2923956 | 0.75 | CCNA2 (0.54) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2921849 | 0.74 | CCNA2 (0.53) | CCNA2CDK2CCNA1CCNB2CCNE2 | |
| SCHEMBL2915619 | 0.72 | CCNA2 (0.50) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2919934 | 0.72 | CDK2 (0.65) | CCNA2CDK2CCNA1CCNB2CCNE2 | |
| SCHEMBL2924986 | 0.72 | CCNA2 (0.49) | CCNA2CDK2CCNA1ALDH1A1AURKA | |
| SCHEMBL4017924 | 0.70 | CCNA2 (0.43) | CCNA2CDK2CCNA1CCNB2CCNE2 | |
| SCHEMBL2920165 | 0.66 | AURKA (0.75) | CCNA2CDK2CCNA1AURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |