Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 12/20 | 0.43 |
| ▸ | CDK2 | P24941 | 12/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.43 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020705 | 0.86 | CCNA2 (0.55) | CCNA2CDK2CCNA1AURKAMAPK1 | |
| SCHEMBL4019871 | 0.84 | CCNA2 (0.47) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2923596 | 0.76 | CCNA2 (0.42) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL2920165 | 0.75 | AURKA (0.75) | CCNA2CDK2CCNA1AURKAFLT3 | |
| SCHEMBL5427278 | 0.71 | CCNA2 (0.49) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL2924419 | 0.71 | CCNA2 (0.57) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL2916133 | 0.70 | CCNA2 (0.61) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL2916852 | 0.70 | CCNA2 (0.49) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL2926410 | 0.70 | CCNA2 (0.41) | CCNA2CDK2CCNA1AURKACCNB2 | |
| SCHEMBL2917126 | 0.69 | AURKA (0.66) | CCNA2CDK2CCNA1AURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531531-B2 | Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles | PFIZER ITALIA S.R.L. (IT) | 2009-05-12 | — | — | US | disclosed |