Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 9/20 | 0.42 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.42 |
| ▸ | AURKA | O14965 | 6/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924758 | 0.92 | KDM4E (0.45) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2923956 | 0.90 | CCNA2 (0.54) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2916852 | 0.88 | CCNA2 (0.49) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2915619 | 0.88 | CCNA2 (0.50) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2924986 | 0.87 | CCNA2 (0.49) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2926410 | 0.84 | CCNA2 (0.41) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2924963 | 0.80 | OPRM1 (0.47) | — | |
| SCHEMBL2919774 | 0.80 | BRD4 (0.36) | CCNA2CDK2CCNA1AURKABRD4 | |
| SCHEMBL2922865 | 0.80 | OPRM1 (0.47) | — | |
| SCHEMBL2920999 | 0.80 | BRD4 (0.36) | CCNA2CDK2CCNA1AURKABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |