Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 0.52 |
| ▸ | MAPT | P10636 | 12/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29265051 | 0.86 | MAPT (0.51) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL29265062 | 0.85 | MAPT (0.52) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL29265077 | 0.83 | MAPT (0.51) | MEN1MAPTKMT2AALDH1A1HPGD | |
| Butyric Acid SCHEMBL29265074 | 0.78 | MAPT (0.53) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL29265072 | 0.78 | MAPT (0.53) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL29265059 | 0.75 | HDAC1 (0.46) | PI4KBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30792220 | 0.74 | PI4KB (0.60) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL30792155 | 0.73 | PI4KB (0.59) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL30997394 | 0.73 | PI4KB (0.59) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL30792253 | 0.72 | PI4KB (0.61) | PI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118221610-A | Phenylthiazole amine PI4KIII beta/HDAC double-target inhibitor, preparation method, pharmaceutical composition and application thereof | 南京市鸿舜医药科技有限公司 | 2024-06-21 | — | — | CN | claimed |
| CN-118221610-A | Phenylthiazole amine PI4KIII beta/HDAC double-target inhibitor, preparation method, pharmaceutical composition and application thereof | 南京市鸿舜医药科技有限公司 | 2024-06-21 | — | — | CN | disclosed |