Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27671365 | 0.98 | MAPT (0.49) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL760760 | 0.87 | MAPT (0.61) | MAPTHPGDCYP3A4NOS1LMNA | |
| SCHEMBL2931498 | 0.81 | JAK2 (0.51) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL921416 | 0.81 | DAO (0.51) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL29431208 | 0.81 | JAK2 (0.51) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL30833662 | 0.81 | DAO (0.51) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL2595091 | 0.80 | MAPT (0.50) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL588431 | 0.80 | PARP1 (0.51) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL445096 | 0.80 | MAPT (0.50) | MAPTHPGDDAOCYP3A4NOS1 | |
| SCHEMBL29395331 | 0.80 | MAPT (0.50) | MAPTHPGDDAOCYP3A4NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3933498-A | Fogged, direct positive silver halide emulsions containing a bleach inhibiting compound and a Dmin maintainer compound | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-01-20 | — | — | US | claimed |
| CN-110536885-B | Process for producing difluoromethylene compound | 佐藤制药株式会社 | 2024-03-08 | — | — | CN | disclosed |
| US-11084792-B2 | Method for producing difluoromethylene compound | SATO PHARMACEUTICAL CO., LTD. (JP) | 2021-08-10 | — | — | US | disclosed |
| US-20200190038-A1 | METHOD FOR PRODUCING DIFLUOROMETHYLENE COMPOUND | SATO PHARMACEUTICAL CO., LTD. (JP) | 2020-06-18 | — | — | US | disclosed |
| EP-3617197-A1 | METHOD FOR PRODUCING DIFLUOROMETHYLENE COMPOUND | Sato Pharmaceutical Co., Ltd. (JP) | 2020-03-04 | — | — | EP | disclosed |
| US-8377983-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| CN-102633783-A | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA INC | 2012-08-15 | — | — | CN | disclosed |
| CN-101379060-B | Benzoxazole-based derivatives as Aurora kinase inhibitors, compositions, and methods of use | TRANSTECH PHARMA INC | 2012-05-23 | — | — | CN | disclosed |
| US-7820821-B2 | Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| EP-1019045-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999000128-A9 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 1999-08-05 | — | — | WO | disclosed |
| WO-1999000128-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-01-07 | — | — | WO | disclosed |
| EP-0448206-B1 | Substituted benzimidazole and indazole derivatives, processes for their preparation and their use as herbicides | ZENECA LTD (GB) | 1994-12-28 | — | — | EP | disclosed |
| US-5306692-A | Herbicidal indazole and benzimidazole compounds | ZENECA LIMITED (GB) | 1994-04-26 | — | — | US | disclosed |
| EP-0448206-A2 | Substituted benzimidazole and indazole derivatives, processes for their preparation and their use as herbicides | ZENECA LIMITED (GB) | 1991-09-25 | — | — | EP | disclosed |
| CN-1054063-A | Heterogeneous ring compound | ICI PLC (GB) | 1991-08-28 | — | — | CN | disclosed |
| US-4020111-A | Propynyloxy alkyl arene insecticides | HENNESSY DOUGLAS J | 1977-04-26 | — | — | US | disclosed |
| US-3954793-A | INSECTICIDES | HENNESSY DOUGLAS J | 1976-05-04 | — | — | US | disclosed |
| US-3933498-A | Fogged, direct positive silver halide emulsions containing a bleach inhibiting compound and a Dmin maintainer compound | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190038-A1 | METHOD FOR PRODUCING DIFLUOROMETHYLENE COMPOUND | HACL2, MGLL, ABL1 | MAPT 4687/4885HPGD 3753/4885DAO 167/4885 |
| US-20100152170-A1 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors | AURKC, AURKA, AURKB | MAPT 1464/4885HPGD 3750/4885DAO 3918/4885 |
| US-11084792-B2 | Method for producing difluoromethylene compound | HACL2, MGLL, ABL1 | MAPT 4687/4885HPGD 3753/4885DAO 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.