Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825571 | 0.85 | MEN1 (0.83) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL7885470 | 0.85 | TNF (0.69) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL825515 | 0.83 | MEN1 (0.71) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL4441275 | 0.82 | KMT2A (0.73) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL825658 | 0.81 | PDE4A (0.72) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL23706096 | 0.80 | MEN1 (1.00) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL825643 | 0.80 | PDE4A (0.61) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL825856 | 0.79 | PDE4A (0.60) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL4445007 | 0.79 | MEN1 (0.72) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL6693021 | 0.79 | TNF (0.70) | ALDH1A1HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431602-B2 | Beta-amino acid derivatives for treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-30 | — | — | US | disclosed |
| EP-2231640-B1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |
| US-20100331346-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-12-30 | — | — | US | disclosed |
| EP-2231640-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009092432-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331346-A1 | BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES | GPR119, GLS, GCKR | MEN1 3909/4885KMT2A 3191/4885MAPT 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.