Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927567 | 0.85 | MAP3K7 (0.64) | MAP3K7CHEK1JAK2JAK1HDAC6 | |
| SCHEMBL1927563 | 0.85 | MAP3K7 (0.64) | MAP3K7CHEK1JAK2JAK1HDAC6 | |
| SCHEMBL2931228 | 0.85 | CHEK1 (0.51) | MAP3K7CHEK1JAK2JAK1HDAC6 | |
| SCHEMBL2928697 | 0.83 | MAP3K7 (0.54) | MAP3K7CHEK1NPC1ALDH1A1LMNA | |
| SCHEMBL1929265 | 0.79 | CHEK1 (0.70) | CHEK1JAK2HDAC6IKBKBMAPK8 | |
| SCHEMBL1929263 | 0.79 | CHEK1 (0.70) | CHEK1JAK2HDAC6IKBKBMAPK8 | |
| SCHEMBL1928012 | 0.74 | IKBKB (0.53) | MAP3K7CHEK1JAK2JAK1HDAC6 | |
| SCHEMBL1928014 | 0.74 | IKBKB (0.53) | MAP3K7CHEK1JAK2JAK1HDAC6 | |
| SCHEMBL4979048 | 0.69 | KDM4E (0.46) | IKBKBKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL5101701 | 0.68 | GRM2 (0.50) | JAK2JAK1HDAC6GRM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |