Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPRA | P18433 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975594 | 0.87 | IKBKB (0.52) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL4975571 | 0.80 | IKBKB (0.62) | KDM4EMAPTRAB9ANPC1CASP3 | |
| SCHEMBL6534391 | 0.76 | PTPN1 (0.75) | KDM4EMAPTALDH1A1POLBLMNA | |
| SCHEMBL3817368 | 0.72 | HPGD (0.56) | KDM4EMAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL5898665 | 0.72 | IKBKB (0.59) | KMT2AMEN1IKBKB | |
| SCHEMBL3809006 | 0.72 | KMT2A (0.51) | KDM4EMAPTALDH1A1LMNAPTPN1 | |
| SCHEMBL1563671 | 0.70 | NPSR1 (0.70) | KDM4EMAPTRAB9ANPC1CASP3 | |
| SCHEMBL3811534 | 0.69 | ACLY (0.52) | KDM4EALDH1A1POLBNPSR1IKBKB | |
| SCHEMBL1382530 | 0.69 | IKBKB (0.78) | KDM4EMAPTRAB9ANPC1CASP3 | |
| SCHEMBL3809896 | 0.68 | ACLY (0.53) | KDM4EMAPTALDH1A1NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448545-B1 | NF-KB INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-11-19 | — | — | EP | claimed |