Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1928700 | 0.84 | MAP3K7 (0.70) | MAP3K7CHEK1HDAC1HRH3SMN1; SMN2 | |
| SCHEMBL2934362 | 0.84 | CHEK1 (0.58) | MAP3K7CHEK1HRH3SMN1; SMN2LMNA | |
| SCHEMBL2926992 | 0.83 | MAP3K7 (0.49) | MAP3K7CHEK1SMN1; SMN2LMNARAB9A | |
| SCHEMBL2931062 | 0.81 | CHEK1 (0.59) | MAP3K7CHEK1HRH3SMN1; SMN2LMNA | |
| SCHEMBL1928109 | 0.78 | CHEK1 (0.80) | MAP3K7CHEK1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2932197 | 0.75 | CHEK1 (0.48) | CHEK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL1926780 | 0.75 | CHEK1 (0.81) | MAP3K7CHEK1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2930060 | 0.74 | CHEK1 (0.70) | MAP3K7CHEK1KMT2AMEN1TBK1 | |
| SCHEMBL2933445 | 0.73 | CHEK1 (0.72) | MAP3K7CHEK1HRH3KMT2AMEN1 | |
| SCHEMBL3510941 | 0.73 | CHEK1 (0.56) | MAP3K7CHEK1HRH3TBK1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |