Sugi Predict

Sugi Predict / Compounds / SCHEMBL2927043

SCHEMBL2927043

SCHEMBL2927043

O=C(O)c1ccc(Nc2cncc(-c3cc4ccccc4[nH]3)n2)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HCAR3 P49019 8/20 0.48
▸ CASP3 P42574 1/20 0.41
▸ SENP8 Q96LD8 1/20 0.41
▸ SENP7 Q9BQF6 1/20 0.41
▸ SENP6 Q9GZR1 1/20 0.41
▸ ITK Q08881 1/20 0.39
▸ ESR1 P03372 1/20 0.39
▸ LDHA P00338 2/20 0.38
▸ GSK3B P49841 1/20 0.38
▸ LDHB P07195 1/20 0.38
▸ SYK P43405 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ DAO P14920 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ SRD5A2 P31213 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ TBK1 Q9UHD2 1/20 0.37
▸ BRAF P15056 1/20 0.36
▸ CYP19A1 P11511 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2928618 0.83 KDM4E (0.52) KDM4E
SCHEMBL2935136 0.82 BCL6 (0.43) CASP3SENP8SENP7SENP6ITK
SCHEMBL2927798 0.81 HRH4 (0.51) —
SCHEMBL2933133 0.81 HRH4 (0.52) SYKKDM4EHPGDHSD17B10
SCHEMBL2932841 0.80 PIM3 (0.48) CASP3SENP8SENP7SENP6LDHA
SCHEMBL2934019 0.79 BRAF (0.47) ITKGSK3BSYKTBK1BRAF
Acetic Acid SCHEMBL2933253 0.78 BRAF (0.47) ITKESR1SYKBRAF
SCHEMBL2933637 0.78 CDK5 (0.55) CASP3SENP8SENP7SENP6ITK
SCHEMBL2932836 0.76 ITK (0.41) ITKBRAF
SCHEMBL2931626 0.76 BRAF (0.39) ITKGSK3BSYKTBK1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044051-B1 PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS BIOVITRUM AB PUBL (SE) 2010-01-27 — — EP disclosed
EP-2044051-B1 PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS BIOVITRUM AB PUBL (SE) 2010-01-27 — — EP disclosed
CN-101472912-A Pyridine and pyrazine derivatives as MNK kinase inhibitors BIOVITRUM AB PUBL (SE) 2009-07-01 — — CN disclosed
EP-2044051-A1 PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS BIOVITRUM AB (publ) (SE) 2009-04-08 — — EP disclosed
US-20080039450-A1 Compounds BIOVITRUM AB (PUBL.) (SE) 2008-02-14 — — US disclosed
US-20080039450-A1 Compounds BIOVITRUM AB (PUBL.) (SE) 2008-02-14 — — US disclosed
US-20080039450-A1 Compounds BIOVITRUM AB (PUBL.) (SE) 2008-02-14 — — US disclosed
WO-2007147874-A1 PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS BIOVITRUM AB (PUBL) (SE) 2007-12-27 — — WO disclosed
WO-2007147874-A1 PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS BIOVITRUM AB (PUBL) (SE) 2007-12-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080039450-A1 Compounds NEK2, CSNK2A3, CSNK2A1 HCAR3 1731/4885CASP3 3930/4885SENP8 4507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.