Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29270852 | 0.84 | PTGDR2 (0.37) | TP53MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29270690 | 0.81 | ALDH1A1 (0.41) | TP53MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL26962034 | 0.81 | XIAP (0.38) | NOTUMRIPK1MAPTLMNAALDH1A1 | |
| SCHEMBL29270774 | 0.80 | KDM4E (0.32) | TP53 | |
| SCHEMBL29270684 | 0.80 | USP30 (0.33) | TP53 | |
| SCHEMBL29270847 | 0.80 | TP53 (0.47) | TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL29270781 | 0.79 | TP53 (0.37) | TP53MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29270777 | 0.78 | CLK1 (0.33) | — | |
| SCHEMBL29270805 | 0.78 | CNR2 (0.34) | — | |
| SCHEMBL29270701 | 0.78 | CNR2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |