Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 9/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936712 | 0.87 | TRPM4 (0.41) | TRPM4NPC1RAB9AGPR84EIF4E | |
| SCHEMBL2933942 | 0.82 | MCL1 (0.40) | GPR84TACR3MCL1 | |
| SCHEMBL2933106 | 0.82 | STING1 (0.39) | TRPM4NPC1RAB9AGPR84EIF4E | |
| SCHEMBL2926074 | 0.80 | NPC1 (0.37) | TRPM4NPC1RAB9AGPR84TACR3 | |
| SCHEMBL2927375 | 0.77 | P2RY14 (0.52) | — | |
| SCHEMBL2934902 | 0.74 | PTGER1 (0.40) | EIF4E | |
| SCHEMBL2930474 | 0.69 | P2RY14 (0.56) | NPC1RAB9A | |
| SCHEMBL2970776 | 0.66 | POLB (0.42) | MCL1 | |
| SCHEMBL15025193 | 0.66 | ACMSD (0.59) | GPR84EIF4E | |
| SCHEMBL2929204 | 0.64 | P2RY14 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229373-A1 | SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009070873-A1 | SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |