Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 3/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934902 | 0.88 | PTGER1 (0.40) | PTGER1EIF4ELTB4RLTB4R2POLB | |
| SCHEMBL2927355 | 0.87 | TRPM4 (0.40) | TRPM4MCL1GPR84NPC1RAB9A | |
| SCHEMBL2933106 | 0.86 | STING1 (0.39) | TRPM4MCL1GPR84NPC1RAB9A | |
| SCHEMBL2933942 | 0.83 | MCL1 (0.40) | MCL1GPR84PTGER1ACMSDLTB4R | |
| SCHEMBL2926074 | 0.80 | NPC1 (0.37) | TRPM4MCL1GPR84NPC1RAB9A | |
| SCHEMBL2929204 | 0.77 | P2RY14 (0.53) | LTB4RLTB4R2 | |
| SCHEMBL2930474 | 0.69 | P2RY14 (0.56) | NPC1RAB9ATDP1 | |
| SCHEMBL15025193 | 0.69 | ACMSD (0.59) | GPR84ACMSDEIF4E | |
| SCHEMBL2970776 | 0.67 | POLB (0.42) | MCL1ACMSDLTB4RLTB4R2POLB | |
| SCHEMBL2931721 | 0.66 | P2RY14 (0.52) | RAB9AKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229373-A1 | SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY | Merck Frosst Canada Ltd. (CA) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009070873-A1 | SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY | MERCK FROSST CANADA LTD. (CA) | 2009-06-11 | — | — | WO | disclosed |