Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 16/20 | 0.49 |
| ▸ | CTSB | P07858 | 10/20 | 0.49 |
| ▸ | CTSK | P43235 | 8/20 | 0.49 |
| ▸ | CTSS | P25774 | 7/20 | 0.49 |
| ▸ | CTSF | Q9UBX1 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3761820 | 0.81 | CTSL (0.69) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL3761818 | 0.81 | CTSL (0.69) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL2927538 | 0.78 | CTSL (0.52) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL2923823 | 0.69 | CTSL (0.56) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL2927752 | 0.69 | CTSL (0.62) | CTSLCTSBCTSKCTSSCTSF | |
| SCHEMBL5762384 | 0.68 | CTSL (0.56) | CTSLCTSBCTSKCTSS | |
| SCHEMBL2155715 | 0.68 | CTSL (0.56) | CTSLCTSBCTSKCTSS | |
| SCHEMBL14201221 | 0.67 | CTSL (0.70) | CTSLCTSBCTSKCTSS | |
| SCHEMBL2155718 | 0.66 | CTSL (1.00) | CTSLCTSBCTSKCTSS | |
| SCHEMBL5061385 | 0.66 | CTSL (1.00) | CTSLCTSBCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225196-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | Merck Frosst Canada Ltd. (CA) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009067797-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK FROSST CANADA LTD. (CA) | 2009-06-04 | — | — | WO | disclosed |