Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.62 |
| ▸ | CTSB | P07858 | 9/20 | 0.62 |
| ▸ | CTSF | Q9UBX1 | 8/20 | 0.62 |
| ▸ | CTSK | P43235 | 8/20 | 0.62 |
| ▸ | CTSS | P25774 | 4/20 | 0.62 |
| ▸ | CTSV | O60911 | 3/20 | 0.62 |
| ▸ | CTSC | P53634 | 6/20 | 0.36 |
| ▸ | EP300 | Q09472 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944796 | 0.83 | CTSL (0.87) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL3761811 | 0.83 | CTSL (0.87) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL2927753 | 0.80 | CTSL (0.66) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL2921279 | 0.77 | CTSL (1.00) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL3769846 | 0.77 | CTSL (1.00) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL3138544 | 0.76 | CTSB (0.68) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL12999198 | 0.74 | CTSL (0.81) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL2927165 | 0.72 | CTSB (0.79) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL2923823 | 0.71 | CTSL (0.56) | CTSLCTSBCTSFCTSKCTSS | |
| SCHEMBL2927535 | 0.69 | CTSL (0.49) | CTSLCTSBCTSFCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225196-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | Merck Frosst Canada Ltd. (CA) | 2010-09-08 | — | — | EP | claimed |
| WO-2009067797-A1 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES | MERCK FROSST CANADA LTD. (CA) | 2009-06-04 | — | — | WO | claimed |