Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 13/20 | 0.75 |
| ▸ | MMP2 | P08253 | 6/20 | 0.75 |
| ▸ | MMP12 | P39900 | 1/20 | 0.75 |
| ▸ | MMP1 | P03956 | 19/20 | 0.55 |
| ▸ | MMP13 | P45452 | 17/20 | 0.55 |
| ▸ | MMP3 | P08254 | 16/20 | 0.55 |
| ▸ | MMP7 | P09237 | 16/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1656118 | 0.92 | MMP9 (0.72) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5546935 | 0.90 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2925250 | 0.90 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655595 | 0.90 | MMP9 (0.75) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656134 | 0.89 | MMP9 (0.73) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656114 | 0.89 | MMP9 (0.73) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1656257 | 0.89 | MMP9 (0.68) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655811 | 0.89 | MMP9 (0.68) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655664 | 0.87 | MMP9 (0.73) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655768 | 0.87 | MMP2 (0.66) | MMP9MMP2MMP12MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768979-B1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCK SERONO SA (CH) | 2010-09-29 | — | — | EP | claimed |
| EP-1768979-A1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-04 | — | — | EP | claimed |
| WO-2006008303-A1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-01-26 | — | — | WO | claimed |