Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2236292 | 0.99 | CRHR1 (0.49) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL29256009 | 0.85 | CRHR1 (0.54) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL2180543 | 0.82 | CRHR1 (0.54) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL2182127 | 0.81 | CRHR1 (0.61) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL22958804 | 0.81 | CRHR1 (0.56) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL27051835 | 0.80 | CRHR1 (0.50) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL29430976 | 0.77 | CRHR1 (0.57) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL25490371 | 0.74 | CRHR1 (0.56) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL2931339 | 0.72 | CRHR1 (0.52) | CRHR1CRHR2KMT2APOLBMEN1 | |
| SCHEMBL25490375 | 0.72 | CRHR1 (0.49) | CRHR1CRHR2KMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |