Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | DHFR | P00374 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 5/20 | 0.54 |
| ▸ | CA2 | P00918 | 5/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfacetamide SCHEMBL5015229 | 0.88 | SMN1; SMN2 (0.69) | SMN1; SMN2DHFRTSHRTDP1KDM4E | |
| SCHEMBL28291995 | 0.86 | TSHR (0.67) | SMN1; SMN2DHFRTSHRTDP1CA1 | |
| SCHEMBL27600086 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2DHFRTSHRTDP1KDM4E | |
| SCHEMBL12700752 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2DHFRTSHRTDP1CA2 | |
| SCHEMBL27582789 | 0.84 | CA1 (0.56) | SMN1; SMN2DHFRTSHRTDP1KDM4E | |
| SCHEMBL4636140 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2DHFRTSHRTDP1KDM4E | |
| SCHEMBL28146078 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2DHFRTSHRTDP1KDM4E | |
| SCHEMBL27319210 | 0.83 | CA1 (0.60) | SMN1; SMN2KDM4EPSIP1CA1CA2 | |
| SCHEMBL13648079 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2DHFRTSHRTDP1KDM4E | |
| SCHEMBL13966984 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2DHFRTSHRTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101460198-B | Thermosensitive polyphosphazene-bioactive molecule conjugate, preparation method and application thereof | KOREA INST SCI & TECH | 2013-08-07 | — | — | CN | disclosed |
| EP-1773791-B1 | PYRROLOTRIAZINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-22 | — | — | EP | disclosed |
| EP-1773791-B1 | PYRROLOTRIAZINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2010-09-22 | — | — | EP | disclosed |
| EP-1773791-A4 | PYRROLOTRIAZINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2009-08-26 | — | — | EP | disclosed |
| CN-101460198-A | Thermosensitive polyphosphazene-bioactive molecule conjugate, preparation method and application thereof | KOREA INST SCI & TECH (KR) | 2009-06-17 | — | — | CN | disclosed |
| EP-1773791-A1 | PYRROLOTRIAZINE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2007-04-18 | — | — | EP | disclosed |
| US-7102003-B2 | Pyrrolotriazine compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-09-05 | — | — | US | disclosed |
| WO-2006007468-A1 | PYRROLOTRIAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-19 | — | — | WO | disclosed |
| US-20060014745-A1 | Pyrrolotriazine compounds | BRISTOL-MYERS SQUIBB COMPANY | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014745-A1 | Pyrrolotriazine compounds | ERBB2, ERBB4, EGFR | SMN1; SMN2 4694/4885DHFR 519/4885TSHR 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.