Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | DHFR | P00374 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23512345 | 0.95 | UCHL1 (0.61) | SMN1; SMN2DHFRTSHRTDP1ALDH1A1 | |
| SCHEMBL13966984 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2DHFRTSHRTDP1ALDH1A1 | |
| SCHEMBL7596737 | 0.85 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1HPGDMAPTPKM | |
| SCHEMBL2928482 | 0.84 | SMN1; SMN2 (0.66) | SMN1; SMN2DHFRTSHRTDP1MAPT | |
| SCHEMBL6859141 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPTUCHL1KMT2A | |
| SCHEMBL13648079 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2DHFRTSHRTDP1ALDH1A1 | |
| SCHEMBL13668104 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2DHFRTSHRTDP1EPHX2 | |
| SCHEMBL791784 | 0.81 | L3MBTL1 (0.62) | SMN1; SMN2DHFRTSHRTDP1ALDH1A1 | |
| SCHEMBL28291995 | 0.81 | TSHR (0.67) | SMN1; SMN2DHFRTSHRTDP1ALDH1A1 | |
| SCHEMBL10285030 | 0.80 | ALDH1A1 (0.68) | SMN1; SMN2DHFRTSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245174-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2012-09-27 | — | — | US | disclosed |
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245174-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | BRAF, ARAF, RAF1 | SMN1; SMN2 4746/4885DHFR 676/4885TSHR 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.