Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11646035 | 0.82 | POLB (0.57) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL13998719 | 0.81 | NPC1 (0.49) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL983700 | 0.81 | MAPT (0.61) | NPC1RAB9APDK1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2906176 | 0.79 | MAPT (0.59) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL13052956 | 0.78 | NPC1 (0.56) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL13310867 | 0.77 | PDK1 (0.58) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL24795860 | 0.76 | NPC1 (0.56) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL984667 | 0.75 | GAA (0.49) | NPC1RAB9APDK1ALDH1A1LMNA | |
| SCHEMBL2902912 | 0.75 | MAPT (0.54) | NPC1RAB9AALDH1A1LMNAHTT | |
| SCHEMBL13998684 | 0.74 | KDM4E (0.61) | NPC1RAB9APDK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |