SCHEMBL2928612

SCHEMBL2928612

CC(C)(C)OC(=O)NCC[C@@H](C(N)=O)N(CCc1cccc(Cl)c1)C(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
KMT2A Q03164 2/20 0.36
CTSL P07711 1/20 0.36
TLR2 O60603 1/20 0.33
TLR1 Q15399 1/20 0.33
EPHX2 P34913 1/20 0.33
MALT1 Q9UDY8 1/20 0.33
IDO1 P14902 1/20 0.33
FNTA P49354 1/20 0.33
FNTB P49356 1/20 0.33
PGGT1B P53609 1/20 0.33
MDM2 Q00987 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
MAPK1 P28482 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2924241 0.89 KMT2A (0.41) KDM4EKMT2ACTSLTLR2TLR1
SCHEMBL2247795 0.83 KMT2A (0.39) KMT2AEPHX2IDO1
SCHEMBL2926699 0.80 KMT2A (0.41) KMT2ACTSLTLR2TLR1MALT1
SCHEMBL29633793 0.76 EPHX2 (0.37) KDM4EKMT2ACTSLEPHX2IDO1
SCHEMBL2928823 0.75 KMT2A (0.38) KMT2ATLR2TLR1MALT1MDM2
SCHEMBL15764515 0.74 CA1 (0.47) KMT2ACTSLTLR2TLR1MDM2
SCHEMBL17133645 0.74 CA1 (0.47) KMT2ACTSLTLR2TLR1MDM2
SCHEMBL31714189 0.74 KMT2A (0.45) KMT2ATLR2TLR1MALT1IDO1
SCHEMBL2924206 0.74 KDM4E (0.40) KDM4ECTSLCYP1A2CYP3A4CYP2C9
SCHEMBL2248824 0.74 KMT2A (0.39) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675824-B1 SOMATOSTATIN RECEPTOR 1 AND/OR 4 SELECTIVE AGONISTS AND ANTAGONISTS WURSTER SIEGFRIED (FI) 2010-09-29 EP disclosed
US-7741362-B2 Somatostatin receptor 1 and/or 4 selective agonists and antagonists SIEGFRIED WURSTER (FI) 2010-06-22 US disclosed
US-20100004339-A1 Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists OY JUVANTIA PHARMA LTD. (FI) 2010-01-07 US disclosed
US-20070129422-A1 Somatostatin receptor 1 and/or 4 selective agonists and antagonists OY JUVANTIA PHARMA LTD (FI) 2007-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129422-A1 Somatostatin receptor 1 and/or 4 selective agonists and antagonists SSTR4, SSTR1, SSTR3 KDM4E 1851/4885KMT2A 2112/4885CTSL 1938/4885
US-20100004339-A1 Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists SSTR4, SSTR1, SSTR3 KDM4E 1851/4885KMT2A 2112/4885CTSL 1938/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.