SCHEMBL2928823

SCHEMBL2928823

CC(C)(C)OC(=O)NCC[C@@H](C(N)=O)N(C(=O)OCC1c2ccccc2-c2ccccc21)C1CCCCC1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.38
MALT1 Q9UDY8 1/20 0.36
TLR2 O60603 1/20 0.36
TLR1 Q15399 1/20 0.36
EPHX1 P07099 1/20 0.35
MDM2 Q00987 1/20 0.35
KCNA5 P22460 1/20 0.35
BACE1 P56817 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2926699 0.81 KMT2A (0.41) KMT2AMALT1TLR2TLR1MDM2
SCHEMBL2252447 0.81 KMT2A (0.41) KMT2A
SCHEMBL2247593 0.81 KMT2A (0.41) KMT2A
SCHEMBL2249667 0.80 KMT2A (0.42) KMT2A
SCHEMBL31714189 0.78 KMT2A (0.45) KMT2AMALT1TLR2TLR1MDM2
SCHEMBL2250139 0.76 KMT2A (0.43) KMT2A
SCHEMBL2928612 0.75 KDM4E (0.39) KMT2AMALT1TLR2TLR1MDM2
SCHEMBL25671629 0.75 KMT2A (0.48) KMT2AMALT1TLR2TLR1MDM2
SCHEMBL2928219 0.74 KMT2A (0.42) KMT2ATLR2TLR1MDM2
SCHEMBL3579032 0.74 HDAC4 (0.49) KMT2ATLR2TLR1EPHX1MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675824-B1 SOMATOSTATIN RECEPTOR 1 AND/OR 4 SELECTIVE AGONISTS AND ANTAGONISTS WURSTER SIEGFRIED (FI) 2010-09-29 EP disclosed
US-7741362-B2 Somatostatin receptor 1 and/or 4 selective agonists and antagonists SIEGFRIED WURSTER (FI) 2010-06-22 US disclosed
US-20100004339-A1 Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists OY JUVANTIA PHARMA LTD. (FI) 2010-01-07 US disclosed
US-20070129422-A1 Somatostatin receptor 1 and/or 4 selective agonists and antagonists OY JUVANTIA PHARMA LTD (FI) 2007-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129422-A1 Somatostatin receptor 1 and/or 4 selective agonists and antagonists SSTR4, SSTR1, SSTR3 KMT2A 2112/4885MALT1 1696/4885TLR2 1820/4885
US-20100004339-A1 Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists SSTR4, SSTR1, SSTR3 KMT2A 2112/4885MALT1 1696/4885TLR2 1820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.