Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927146 | 0.84 | BRAF (0.37) | BRAFTTKFLT3CCNA2CDK2 | |
| SCHEMBL2960852 | 0.83 | BRAF (0.37) | BRAFTTKFLT3CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL2928643 | 0.80 | PTK2 (0.39) | TTKCCNA2CDK2ALDH1A1AURKA | |
| SCHEMBL2927992 | 0.79 | ALDH1A1 (0.40) | BRAFTTKCCNA2CDK2ALDH1A1 | |
| SCHEMBL2928408 | 0.79 | PIM3 (0.46) | BRAFTTKFLT3CCNA2CDK2 | |
| SCHEMBL14269675 | 0.78 | TTK (0.43) | BRAFTTKCCNA2CDK2 | |
| SCHEMBL13515312 | 0.76 | KDR (0.46) | ALDH1A1AURKA | |
| Trifluoroacetic Acid SCHEMBL2928635 | 0.75 | DYRK1A (0.47) | TTK | |
| Trifluoroacetic Acid SCHEMBL2960848 | 0.75 | TMEM97 (0.40) | CCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL2936353 | 0.75 | MKNK1 (0.49) | BRAFTTKCCNA2CDK2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |