Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933039 | 0.90 | CHEK1 (0.73) | CHEK1MAP3K7IKBKETBK1IKBKB | |
| SCHEMBL2930060 | 0.89 | CHEK1 (0.70) | CHEK1MAP3K7TBK1IKBKBMEN1 | |
| SCHEMBL2933445 | 0.88 | CHEK1 (0.72) | CHEK1HRH3MAP3K7IKBKBMEN1 | |
| SCHEMBL2934362 | 0.86 | CHEK1 (0.58) | CHEK1HRH3MAP3K7TBK1IKBKB | |
| SCHEMBL2932566 | 0.85 | CHEK1 (0.57) | CHEK1MAP3K7IKBKBMEN1KMT2A | |
| SCHEMBL1927925 | 0.85 | CHEK1 (0.81) | CHEK1HRH3MAP3K7IKBKETBK1 | |
| SCHEMBL2933336 | 0.84 | CHEK1 (0.56) | CHEK1HRH3MAP3K7IKBKBMEN1 | |
| SCHEMBL2932338 | 0.83 | CHEK1 (0.55) | CHEK1HRH3MAP3K7IKBKBJAK2 | |
| SCHEMBL2931062 | 0.83 | CHEK1 (0.59) | CHEK1HRH3MAP3K7TBK1IKBKB | |
| SCHEMBL2931228 | 0.82 | CHEK1 (0.51) | CHEK1MAP3K7IKBKBJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |