Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.72 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930060 | 0.99 | CHEK1 (0.70) | CHEK1MAP3K7IKBKBKDM4EMEN1 | |
| SCHEMBL2931062 | 0.90 | CHEK1 (0.59) | CHEK1MAP3K7IKBKBHPGDALDH1A1 | |
| SCHEMBL2934362 | 0.90 | CHEK1 (0.58) | CHEK1MAP3K7IKBKBMEN1KMT2A | |
| SCHEMBL2933039 | 0.90 | CHEK1 (0.73) | CHEK1MAP3K7IKBKB | |
| SCHEMBL2932566 | 0.89 | CHEK1 (0.57) | CHEK1MAP3K7IKBKBMEN1KMT2A | |
| SCHEMBL2933336 | 0.88 | CHEK1 (0.56) | CHEK1MAP3K7IKBKBMEN1KMT2A | |
| SCHEMBL2928699 | 0.88 | CHEK1 (0.59) | CHEK1MAP3K7IKBKBMEN1KMT2A | |
| SCHEMBL2932338 | 0.87 | CHEK1 (0.55) | CHEK1MAP3K7IKBKBHRH3 | |
| SCHEMBL2932064 | 0.86 | CHEK1 (0.54) | CHEK1MAP3K7IKBKBMAPTALDH1A1 | |
| SCHEMBL2933338 | 0.85 | CHEK1 (0.52) | CHEK1MAP3K7IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |