Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31475217 | 0.86 | CXCR4 (0.47) | KDM4EALDH1A1PRMT6KDR | |
| SCHEMBL2929383 | 0.79 | LMNA (0.50) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL8038019 | 0.78 | MC4R (0.51) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL24027019 | 0.77 | LMNA (0.56) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL17331777 | 0.77 | MC4R (0.54) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL12650851 | 0.77 | MC4R (0.50) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL2933524 | 0.77 | MC4R (0.50) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL12606991 | 0.76 | ALDH1A1 (0.53) | MC4RCHKALMNAKDM4EALDH1A1 | |
| SCHEMBL30786270 | 0.75 | HRH3 (0.54) | — | |
| SCHEMBL18713013 | 0.75 | LOX (0.53) | MC4RCHKALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |