Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 14/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 14/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932484 | 0.92 | HCRTR2 (0.41) | GRM2HCRTR1HCRTR2 | |
| SCHEMBL3415880 | 0.88 | CDK4 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL2925299 | 0.88 | CDK4 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL2926155 | 0.86 | HDAC7 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL2930523 | 0.86 | HCRTR2 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL2931971 | 0.85 | HCRTR1 (0.36) | GRM2HCRTR1HCRTR2 | |
| SCHEMBL2928983 | 0.84 | GRM2 (0.40) | GRM2HCRTR1HCRTR2PPIALMNA | |
| SCHEMBL2925064 | 0.84 | HCRTR2 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL2929658 | 0.84 | HCRTR2 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL2929505 | 0.84 | HCRTR2 (0.43) | HCRTR1HCRTR2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |