Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | NQO2 | P16083 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL28218715 | 1.00 | MAPT (0.65) | MAPTNQO2KMT2AMEN1POLB | |
| Acridine SCHEMBL2584619 | 0.85 | MAPT (0.71) | MAPTNQO2KMT2AMEN1POLB | |
| Phenazine SCHEMBL9049 | 0.80 | MAPT (1.00) | MAPTNQO2KMT2AMEN1POLB | |
| Phenazine SCHEMBL29356959 | 0.80 | MAPT (1.00) | MAPTNQO2KMT2AMEN1POLB | |
| Phenazine SCHEMBL27643128 | 0.80 | MAPT (1.00) | MAPTNQO2KMT2AMEN1POLB | |
| Quinoxaline SCHEMBL7039887 | 0.78 | ALDH1A1 (0.44) | MAPTKMT2AMEN1POLBUSP2 | |
| Naphthalene SCHEMBL15929321 | 0.78 | CYP2A6 (0.57) | ALDH1A1HSD17B10TDP1ACHETSHR | |
| Phenazine SCHEMBL6329249 | 0.77 | MAPT (0.92) | MAPTNQO2KMT2AMEN1POLB | |
| Phenazine SCHEMBL20475337 | 0.77 | MAPT (0.92) | MAPTNQO2KMT2AMEN1POLB | |
| Phenazine SCHEMBL3119916 | 0.77 | MAPT (0.92) | MAPTNQO2KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106750254-B | The 10-hydroxycamptothecine water-soluble macromolecule conjugate and preparation method and application of pH sensitivity release | 郑州大学 | 2019-05-24 | — | — | CN | disclosed |