Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 2/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 2/20 | 1.00 |
| ▸ | GABRA5 | P31644 | 2/20 | 1.00 |
| ▸ | GABRA3 | P34903 | 2/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 2/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 2/20 | 1.00 |
| ▸ | GABRP | O00591 | 1/20 | 1.00 |
| ▸ | GABRD | O14764 | 1/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 1/20 | 1.00 |
| ▸ | GABRA4 | P48169 | 1/20 | 1.00 |
| ▸ | GABRE | P78334 | 1/20 | 1.00 |
| ▸ | GABRA6 | Q16445 | 1/20 | 1.00 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 1.00 |
| ▸ | GABRG3 | Q99928 | 1/20 | 1.00 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 1.00 |
| ▸ | CCKBR | P32239 | 13/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | BRD2 | P25440 | 1/20 | 0.56 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923672 | 1.00 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1835654 | 1.00 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9866516 | 0.90 | GABRP (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9432239 | 0.90 | GABRP (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9432242 | 0.90 | GABRP (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9432235 | 0.90 | GABRP (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9866526 | 0.90 | GABRP (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9866520 | 0.90 | GABRP (0.82) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3286663 | 0.89 | GABRP (0.80) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3287270 | 0.89 | GABRP (0.80) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | claimed |
| EP-0253571-B1 | PROCESS FOR RESOLUTION AND RACE MIZATION OF AMINES WITH ACIDIC ALPHA-HYDROGENS | MERCK & CO. INC. (US) | 1989-08-23 | — | — | EP | claimed |
| US-4859771-A | Process for resolution and racemization of amines with acidic α-hydrogens | MERCK & CO., INC. (US) | 1989-08-22 | — | — | US | claimed |
| EP-0253571-A1 | Process for resolution and race mization of amines with acidic alpha-hydrogens | MERCK & CO. INC. (US) | 1988-01-20 | — | — | EP | claimed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | claimed |
| EP-2897954-B1 | FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2897954-B1 | FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2897941-B1 | PRODRUGS OF 1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-09-07 | — | — | EP | disclosed |
| EP-2897941-B1 | PRODRUGS OF 1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-09-07 | — | — | EP | disclosed |
| US-20160060232-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060232-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060232-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-03-03 | — | — | US | disclosed |
| EP-0387618-A1 | 1,7-Fused 1H-indole-2-carboxylic N-(1,4-benzodiazepin-3-yl)-amides | Kali-Chemie Pharma GmbH (DE) | 1990-09-19 | — | — | EP | disclosed |
| EP-0385735-A1 | Benzodiazepine analogs | BIOMEASURE, INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0253571-B1 | PROCESS FOR RESOLUTION AND RACE MIZATION OF AMINES WITH ACIDIC ALPHA-HYDROGENS | MERCK & CO. INC. (US) | 1989-08-23 | — | — | EP | disclosed |
| US-4859771-A | Process for resolution and racemization of amines with acidic α-hydrogens | MERCK & CO., INC. (US) | 1989-08-22 | — | — | US | disclosed |
| US-4820834-A | Benzodiazepine analogs | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0253571-A1 | Process for resolution and race mization of amines with acidic alpha-hydrogens | MERCK & CO. INC. (US) | 1988-01-20 | — | — | EP | disclosed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060232-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS | CNR1, CNR2, NR1I3 | GABRA1 146/4885GABRG2 336/4885GABRB3 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.